ntdB [2017-8-11 16:0:3]

kanosamine-6-phosphate phosphatase

locus: BSU10540

pI: 5.35

mw: 33.05 kDa

protein length: 286 aa

gene length: 858 bp

function: synthesis of the antibiotic kanosamine

product: kanosamine-6-phosphate phosphatase

essential: no

synonyms: yhjK

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.6|Miscellaneous metabolic pathways] → [category|SW 2.6.6.1|Biosynthesis of antibacterial compounds]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.15|Biosynthesis of antibacterial compounds]

Gene

Coordinates: 1,127,466 → 1,128,314

The protein

Catalyzed reaction/ biological activity

• kanosamine-6-phosphate -→ kanosamine [Pubmed|23586652]

Protein family

• [SW|HAD superfamily]
• Cof family (according to Swiss-Prot)

Structure

• [PDB|3GYG]

Expression and Regulation

Operons

• genes: [gene|2F850E2DFA6287DB3890243803E06FDE7ACDB10E|ntdA]-[gene|A4DE6C394B64813A732255734758403241FFAC2F|ntdB]-[gene|29DAF5343A42EAD8DB97925FE7D049410F7B7FCA|ntdC]-[gene|ADB476B0B385D9B9CAF02902CE115C8309F67911|glcP]
  description: [Pubmed|17056753]

  sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|14612444], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

  regulatory mechanism

  • [protein|9118A36CD30E7C99697B3659BB04E03BB7EE71D7|NtdR]: activation, in [regulon|9118A36CD30E7C99697B3659BB04E03BB7EE71D7|NtdR regulon]

  regulation

  • induced by 3,3'-neotrehalosadiamine ([protein|search|NtdR]) [Pubmed|14612444]

Biological materials

Mutant

• MGNA-A724 (yhjK::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/724 NBRP B. subtilis, Japan]

References

Reviews

• 21512256

Original publications

• 19087206,17056753,14612444,23586652